TLR2 in murine atherosclerosis

Peter S Tobias; Linda K Curtiss

doi:10.1007/s00281-007-0102-3

TLR2 in murine atherosclerosis

Semin Immunopathol. 2008 Feb;30(1):23-7. doi: 10.1007/s00281-007-0102-3. Epub 2007 Dec 6.

Authors

Peter S Tobias¹, Linda K Curtiss

Affiliation

¹ Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. [email protected]

PMID: 18058099
DOI: 10.1007/s00281-007-0102-3

Abstract

Atherosclerosis was once thought to be solely a disease of lipid accumulation in the vessel wall. It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis.

Publication types

Review

MeSH terms

Animals
Atherosclerosis / immunology*
Atherosclerosis / metabolism
Disease Models, Animal
Endothelial Cells / immunology*
Endothelial Cells / metabolism
Inflammation / immunology
Inflammation / metabolism
Mice
Mice, Knockout
Signal Transduction
Toll-Like Receptor 2 / immunology
Toll-Like Receptor 2 / metabolism*
Toll-Like Receptor 4 / immunology
Toll-Like Receptor 4 / metabolism

Substances

Toll-Like Receptor 2
Toll-Like Receptor 4