Endometrial cancer associated with defective DNA mismatch repair

Pamela T Soliman; Karen Lu

doi:10.1016/j.ogc.2007.09.003

Endometrial cancer associated with defective DNA mismatch repair

Obstet Gynecol Clin North Am. 2007 Dec;34(4):701-15, viii. doi: 10.1016/j.ogc.2007.09.003.

Authors

Pamela T Soliman¹, Karen Lu

Affiliation

¹ Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Houston, TX 77030, USA.

PMID: 18061865
DOI: 10.1016/j.ogc.2007.09.003

Abstract

Defective DNA mismatch repair is one of the most common and best-characterized genetic defects detected in endometrial cancer. Defective DNA mismatch repair in endometrial cancer can be either inherited or acquired (sporadic). This article describes the clinical and pathologic significance of acquired and inherited defective DNA mismatch repair in endometrial cancer.

Publication types

Review

MeSH terms

DNA Mismatch Repair*
DNA Repair / genetics
DNA Replication / genetics
Endometrial Neoplasms / genetics*
Endometrial Neoplasms / pathology
Endometrial Neoplasms / prevention & control
Female
Genetic Predisposition to Disease
Humans