Abstract
Mx proteins are interferon-induced members of the dynamin superfamily of large GTPases. They inhibit a wide range of viruses by blocking an early stage of the replication cycle. Studies in genetically defined mouse strains highlight their powerful action in early antiviral host defence.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antiviral Agents* / classification
-
Antiviral Agents* / metabolism
-
Antiviral Agents* / pharmacology
-
Cattle
-
Dogs
-
GTP Phosphohydrolases* / classification
-
GTP Phosphohydrolases* / metabolism
-
GTP Phosphohydrolases* / pharmacology
-
GTP-Binding Proteins* / classification
-
GTP-Binding Proteins* / metabolism
-
GTP-Binding Proteins* / pharmacology
-
Humans
-
Interferons / pharmacology*
-
Mice
-
Myxovirus Resistance Proteins
-
Rats
-
Virus Replication / drug effects
-
Viruses / drug effects*
Substances
-
Antiviral Agents
-
Mx1 protein, mouse
-
Myxovirus Resistance Proteins
-
Interferons
-
GTP Phosphohydrolases
-
GTP-Binding Proteins