Abstract
A series of derivatives of bakuchiol were synthesized and tested in vitro for their cytotoxicity, and inhibition of T cell proliferation and B cell proliferation. The data obtained provided preliminary structure-activity relationships of the compounds as immunosuppressive activity.
MeSH terms
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Animals
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Cell Proliferation / drug effects
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Cells, Cultured
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Concanavalin A / pharmacology
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Cytoprotection / drug effects
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / pharmacology*
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Lipopolysaccharides / pharmacology
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Lymphocytes / cytology
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Lymphocytes / drug effects
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Mice
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Molecular Structure
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Phenols / chemical synthesis*
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Phenols / chemistry
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Phenols / pharmacology*
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Structure-Activity Relationship
Substances
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Immunosuppressive Agents
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Lipopolysaccharides
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Phenols
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Concanavalin A
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bakuchiol