A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other gram-negative pathogens. Part 2: Synthesis and structure-activity relationships

Bioorg Med Chem. 2008 Feb 15;16(4):1632-47. doi: 10.1016/j.bmc.2007.11.028. Epub 2007 Nov 17.

Abstract

A novel series of 7beta-[2-(2-amino-5-chloro-thiazol-4-yl)-2(Z)-((S)-1-carboxyethoxyimino)acetamido]cephalosporins bearing various pyridinium groups at the C-3' position were synthesized and their in vitro antibacterial activities against gram-negative pathogens including Pseudomonas aeruginosa and several gram-positive pathogens were evaluated. Among the cephalosporins prepared, we found that a cephalosporin bearing the 2-amino-1-(3-methylamino-propyl)-1H-imidazo[4,5-b]pyridinium group at the C-3' position (8a) showed potent and well-balanced antibacterial activities against P. aeruginosa and other gram-negative pathogens including the strains which produce class C beta-lactamase and extended spectrum beta-lactamase (ESBL). Compound 8a also showed efficacious in vivo activity and high stability against AmpC beta-lactamase. These findings indicate that 2-aminoimidazopyridinium having an aminoalkyl group at the 1-position as a C-3' side chain is suitable for cephalosporins bearing an aminochlorothiazolyl moiety and a carboxyethoxyimino moiety on the C-7 side chain.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Cephalosporins / chemical synthesis
  • Cephalosporins / chemistry*
  • Gram-Negative Bacteria / drug effects
  • Pseudomonas aeruginosa / drug effects*
  • Pyridines
  • Structure-Activity Relationship
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Pyridines
  • beta-Lactamases
  • pyridine