[Application of enzyme-labeled probe in testing of transgenic plant]

Yi Chuan. 2007 Dec;29(12):1533-7.
[Article in Chinese]

Abstract

Used alkaline-phosphatase-labeled DNA as a probe to examine the expression of foreign UidA gene in transgenic plants. Alkaline phosphatase coupled with polyethyleneimine (PEI) using P-benzoquine as the cross-linking reagent was covalently linked to single-stranded DNA via glutraldehyde. Such DNA-enzyme complexes were used as a probe for dot hybridization and Southern blot. After hybridization and incubation with a substrate solution, results can be observed directly in three to six hours and the results showed that it was a sensitive, specific, rapid, safe and economical probe. Dot hybridization analysis showed that the UidA gene was transformed into the target plants and southern blot showed that there were at least 5 copies of UidA gene in transgenic plants.

Publication types

  • English Abstract

MeSH terms

  • Alkaline Phosphatase / metabolism*
  • DNA Probes / genetics
  • DNA Probes / metabolism*
  • DNA, Viral / genetics
  • DNA, Viral / metabolism
  • Hepatitis B virus / genetics
  • Nucleic Acid Hybridization
  • Phosphorus Radioisotopes / metabolism
  • Plants, Genetically Modified / genetics*
  • Sensitivity and Specificity
  • Staining and Labeling
  • Transgenes / genetics

Substances

  • DNA Probes
  • DNA, Viral
  • Phosphorus Radioisotopes
  • Alkaline Phosphatase