Synthesis and characterization of tetra-end linked oligonucleotides capable of forming monomolecular G-quadruplexes

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1231-6. doi: 10.1080/15257770701528172.

Abstract

The chemical synthesis of two new G-rich Tetra-End-Linked-oligodeoxyribonucleotides (TEL-ODNs) as well as (1)H-NMR and CD spectra of the corresponding monomolecular quadruplexes (IVa and IVb) has been reported. The new TEL-ODNs, characterized by the presence of short branches in the linker moiety, could be very useful for the achievement of monomolecular quadruplexes with predetermined strand orientation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • G-Quadruplexes*
  • Guanosine / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Nucleic Acid Conformation*
  • Oligodeoxyribonucleotides / chemical synthesis
  • Oligodeoxyribonucleotides / chemistry*

Substances

  • Oligodeoxyribonucleotides
  • Guanosine