CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1363-7. doi: 10.1080/15257770701533958.

Abstract

Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • Cytosine / chemistry*
  • DNA / chemistry*
  • Guanine / chemistry*
  • Hydrogen Bonding
  • Nucleosides / chemistry
  • Pyrimidinones / chemistry*
  • Pyrroles / chemistry*

Substances

  • N-methyl-3H-pyrrolo(2,3-d)pyrimidin-2(7H)-one
  • Nucleosides
  • Pyrimidinones
  • Pyrroles
  • triplex DNA
  • Guanine
  • Cytosine
  • DNA