Toward a catalytic site in DNA: polyaza crown ether as non-nucleosidic building blocks in DNA conjugates

Ulla Jakobsen; Katja Rohr; Stefan Vogel

doi:10.1080/15257770701539260

Toward a catalytic site in DNA: polyaza crown ether as non-nucleosidic building blocks in DNA conjugates

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1419-22. doi: 10.1080/15257770701539260.

Authors

Ulla Jakobsen¹, Katja Rohr, Stefan Vogel

Affiliation

¹ Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

PMID: 18066796
DOI: 10.1080/15257770701539260

Abstract

A number of functionalized polyaza crown ether building blocks have been incorporated into DNA-conjugates as catalytic Cu(2+) binding sites. The effect of the DNA-conjugate catalyst on the stereochemical outcome of a Cu(2+)-catalyzed Diels-Alder reaction will be presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalytic Domain
Copper / chemistry*
Crown Ethers / chemistry*
DNA, Single-Stranded / chemistry*
Oligonucleotides / chemistry*
Stereoisomerism

Substances

Crown Ethers
DNA, Single-Stranded
Oligonucleotides
Copper