Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1447-50. doi: 10.1080/15257770701542330.

Abstract

In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA / pharmacology*
  • HMGB1 Protein / antagonists & inhibitors*
  • Humans
  • Oligonucleotides / chemistry*
  • Oligonucleotides / pharmacology*

Substances

  • HMGB1 Protein
  • Oligonucleotides
  • locked nucleic acid
  • DNA