Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods

J Comb Chem. 2008 Jan-Feb;10(1):3-19. doi: 10.1021/cc7001205. Epub 2007 Dec 8.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Combinatorial Chemistry Techniques* / methods
  • Combinatorial Chemistry Techniques* / statistics & numerical data
  • Complex Mixtures / chemistry*
  • Drug Design*
  • Drug Evaluation, Preclinical* / methods
  • Drug Evaluation, Preclinical* / statistics & numerical data
  • Humans
  • Pharmaceutical Preparations / chemistry*
  • Small Molecule Libraries / chemistry*

Substances

  • Complex Mixtures
  • Pharmaceutical Preparations
  • Small Molecule Libraries