Abstract
Accumulating evidences suggest that many molecules are working as inhibitors of proliferation in myeloma cells e.g., PTEN, mTOR(PI3-kinase signal molecules), p53, RB1, INK4 family and KIP/CIP family (cell cycle check point molecules), PF4 (inhibitor of angiogenesis). In this review, significance of these molecules in myeloma is summarized. Additionally, our finding of growth inhibitory effect by PU.1 is explained.
MeSH terms
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Cell Division / genetics*
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Cyclin-Dependent Kinase Inhibitor Proteins / physiology
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Cyclin-Dependent Kinase Inhibitor p27 / physiology
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Humans
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Multiple Myeloma / genetics*
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Multiple Myeloma / pathology*
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PTEN Phosphohydrolase / physiology
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Plasma Cells / cytology*
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Plasma Cells / pathology
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Platelet Factor 4 / physiology
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Protein Kinases / physiology
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Proto-Oncogene Proteins / physiology
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TOR Serine-Threonine Kinases
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Trans-Activators / physiology
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Tumor Suppressor Protein p53 / physiology
Substances
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Cyclin-Dependent Kinase Inhibitor Proteins
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Proto-Oncogene Proteins
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Trans-Activators
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Tumor Suppressor Protein p53
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proto-oncogene protein Spi-1
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Cyclin-Dependent Kinase Inhibitor p27
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Platelet Factor 4
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Protein Kinases
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MTOR protein, human
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TOR Serine-Threonine Kinases
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PTEN Phosphohydrolase
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PTEN protein, human