Hybrid photoacoustic fluorescence molecular tomography using finite-element-based inversion

Med Phys. 2007 Nov;34(11):4293-301. doi: 10.1118/1.2786866.

Abstract

Improvements in fluorescence reconstruction when utilizing a hybrid photoacoustic (PAT) fluorescence molecular tomography (FMT) method to image optically heterogeneous media are studied and showcased. Quantitative optical absorption maps are retrieved using a normalized backprojection algorithm for PAT reconstruction. Consecutively, the reconstructed absorption distribution is employed into computing a diffusion-equation-based forward model for FMT using a finite-element solution. The potential promise of the suggested method is experimentally verified on tissue-mimicking fluorescent phantoms, where improvements in the quality of FMT reconstructions are observed when imaging at the presence of a large absorber.

MeSH terms

  • Absorption
  • Acoustics*
  • Algorithms
  • Calibration
  • Diffusion
  • Equipment Design
  • Finite Element Analysis
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Image Processing, Computer-Assisted / methods*
  • Lasers
  • Models, Statistical
  • Phantoms, Imaging
  • Tomography, Optical / methods*
  • Tomography, X-Ray Computed / methods*