Abstract
Spatiotemporal activity patterns in local neural networks are fundamental to brain function. Network activity can now be measured in vivo using two-photon imaging of cell populations that are labeled with fluorescent calcium indicators. In this review, we discuss basic aspects of in vivo calcium imaging and highlight recent developments that will help to uncover operating principles of neural circuits.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Action Potentials
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Animals
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Artifacts
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Calcium Signaling*
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Fluorescent Dyes / chemistry
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Humans
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Imaging, Three-Dimensional
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Microscopy, Fluorescence, Multiphoton / methods*
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Models, Neurological
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Nerve Net / metabolism*
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Neuroglia / metabolism*
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Neurons / metabolism*
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Neuropil / chemistry
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Reproducibility of Results
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Signal Processing, Computer-Assisted
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Time Factors