[Non-small cell lung cancer - diagnostics and stage-adapted therapy]

Med Klin (Munich). 2007 Dec 15;102(12):981-8; quiz 989-90. doi: 10.1007/s00063-007-1122-4.
[Article in German]

Abstract

Non-small cell lung cancer is a common disease. Adeno- and squamous-cell type are the most frequent subtypes, the former with rising incidence. The clinical picture is nonspecific until late in the course of the disease. The most important diagnostic tools are chest X-ray, computed tomogram of the chest, and bronchoscopy. Additional tests often used for staging are abdominal ultrasound, computed tomography of the abdomen, bone scintigraphy, and magnetic resonance imaging of the head. Positron emission tomography is of rising importance. Therapy is guided by stage. Stage I disease is a domain of surgery, in stage II combined with adjuvant chemotherapy. In stage III, multimodality treatment, mostly chemoradiotherapy, is indicated. Stage IV disease is treated with palliative chemotherapy. Newer, so-called targeted therapies are more and more implemented into therapy. There are three substances approved for second-line therapy with response rates of just under 10%.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adenocarcinoma* / diagnosis
  • Adenocarcinoma* / diagnostic imaging
  • Adenocarcinoma* / drug therapy
  • Adenocarcinoma* / mortality
  • Adenocarcinoma* / pathology
  • Adenocarcinoma* / radiotherapy
  • Adenocarcinoma* / surgery
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use
  • Bronchoscopy
  • Carcinoma, Non-Small-Cell Lung* / diagnosis
  • Carcinoma, Non-Small-Cell Lung* / diagnostic imaging
  • Carcinoma, Non-Small-Cell Lung* / mortality
  • Carcinoma, Non-Small-Cell Lung* / pathology
  • Carcinoma, Non-Small-Cell Lung* / surgery
  • Carcinoma, Squamous Cell* / diagnosis
  • Carcinoma, Squamous Cell* / diagnostic imaging
  • Carcinoma, Squamous Cell* / drug therapy
  • Carcinoma, Squamous Cell* / mortality
  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / radiotherapy
  • Carcinoma, Squamous Cell* / surgery
  • Chemotherapy, Adjuvant
  • Humans
  • Lung / pathology
  • Lung Neoplasms* / diagnosis
  • Lung Neoplasms* / diagnostic imaging
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / mortality
  • Lung Neoplasms* / pathology
  • Lung Neoplasms* / radiotherapy
  • Lung Neoplasms* / surgery
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging
  • Meta-Analysis as Topic
  • Neoplasm Staging
  • Positron-Emission Tomography
  • Radiography, Thoracic
  • Radiotherapy, Adjuvant
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antineoplastic Agents