Abstract
Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels, we measured the levels in rats across 24h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamine / pharmacology
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Animals
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Benzhydryl Compounds / pharmacology
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Brain / drug effects
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Brain / metabolism*
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Central Nervous System Stimulants / pharmacology
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Circadian Rhythm / drug effects
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Circadian Rhythm / physiology
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Disorders of Excessive Somnolence / cerebrospinal fluid*
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Disorders of Excessive Somnolence / physiopathology
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Food Deprivation / physiology
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Histamine / cerebrospinal fluid*
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Male
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Modafinil
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Motor Activity / drug effects
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Motor Activity / physiology
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Piperidines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Sleep / drug effects
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Sleep / physiology*
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Sleep Deprivation / metabolism
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Sleep Deprivation / physiopathology
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Synaptic Transmission / physiology*
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Wakefulness / drug effects
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Wakefulness / physiology*
Substances
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Benzhydryl Compounds
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Central Nervous System Stimulants
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Piperidines
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Histamine
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Amphetamine
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thioperamide
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Modafinil