Treatment with tigecycline of recurrent urosepsis caused by extended-spectrum-beta-lactamase-producing Escherichia coli

J Clin Microbiol. 2008 Feb;46(2):817-20. doi: 10.1128/JCM.01340-07. Epub 2007 Dec 12.

Abstract

A 25-year-old female was admitted to our intensive care unit with septic shock and multiorgan failure caused by extended-spectrum beta-lactamase-producing Escherichia coli originating from the right renal pelvis. A 16-day course of treatment with meropenem reversed the septic condition, but the infection recurred thereafter. The patient recovered fully after therapy was changed to tigecycline.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Escherichia coli / drug effects*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / drug therapy*
  • Escherichia coli Infections / microbiology
  • Female
  • Humans
  • Meropenem
  • Minocycline / analogs & derivatives*
  • Minocycline / therapeutic use
  • Recurrence
  • Shock, Septic / drug therapy*
  • Shock, Septic / microbiology
  • Thienamycins / therapeutic use
  • Tigecycline
  • Urinary Tract Infections / complications
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology
  • beta-Lactam Resistance*
  • beta-Lactamases / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • Tigecycline
  • beta-Lactamases
  • Meropenem
  • Minocycline