Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa

J Clin Microbiol. 2008 Feb;46(2):754-6. doi: 10.1128/JCM.02142-07. Epub 2007 Dec 12.

Abstract

Hepatitis B virus (HBV) surface antigen (HBsAg) was found in 9.2% of 1,186 pregnant women from Gabon, of whom 10.1% had the HBe antigen and 89.9% had anti-HBe antibodies. Antibodies to the hepatitis delta virus (HDV) were found in 15.6% of the HBsAg-positive women. The HBV strains were of the A3 and E genotypes. The HDV strains belonged to HDV clades 1 and 8. These results provide clear evidence that HDV clade 8 is indigenous to Africa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cluster Analysis
  • Endemic Diseases*
  • Gabon / epidemiology
  • Genetic Variation*
  • Hepatitis Antibodies / blood
  • Hepatitis B / epidemiology*
  • Hepatitis B / virology
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B e Antigens / blood
  • Hepatitis B virus / genetics*
  • Hepatitis B virus / isolation & purification
  • Hepatitis D / epidemiology*
  • Hepatitis D / virology
  • Hepatitis Delta Virus / genetics*
  • Hepatitis Delta Virus / isolation & purification
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Pregnant People
  • Sequence Analysis, DNA
  • Seroepidemiologic Studies

Substances

  • Hepatitis Antibodies
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens

Associated data

  • GENBANK/EU035518
  • GENBANK/EU035519
  • GENBANK/EU035520
  • GENBANK/EU035538
  • GENBANK/EU035539
  • GENBANK/EU035540
  • GENBANK/EU035541
  • GENBANK/EU035542
  • GENBANK/EU035543
  • GENBANK/EU035544
  • GENBANK/EU035545
  • GENBANK/EU035546
  • GENBANK/EU035547
  • GENBANK/EU035548
  • GENBANK/EU035549
  • GENBANK/EU035550
  • GENBANK/EU035551
  • GENBANK/EU035552