Abstract
Expression of Eag1 was detected in resected esophageal squamous cell carcinomas tissues and matched tissues by immunohistochemistry and RT-PCR. Positive expression of Eag1 protein was 75% (51/68), and mRNA was 73% (8/11) in primary cancer tissues. Eag1 protein positively stained in all 10 metastatic lymph nodes. Eag1 protein and mRNA were negatively expressed in all non-cancerous matched tissues. Eag1 protein was associated with depth of penetration (P = 0.023), but not associated with other clinicopathological factors. Eag1 protein positive group had a significantly shorter survival time than the negative group (P = 0.005). Survival rates at each time-point for the positive group were lower than that for the negative group (P = 0.006), and Eag1 was identified as an independent prognostic factor of long-term survival (P = 0.016). In conclusion, Eag1 was aberrantly expressed in ESCC and correlated with poor prognosis after surgery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Biomarkers, Tumor / analysis*
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Biomarkers, Tumor / genetics
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Carcinoma, Squamous Cell / chemistry*
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / surgery
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Esophageal Neoplasms / chemistry*
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Esophageal Neoplasms / genetics
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Esophageal Neoplasms / mortality
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Esophageal Neoplasms / pathology
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Esophageal Neoplasms / surgery
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Esophagectomy*
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Ether-A-Go-Go Potassium Channels / analysis*
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Ether-A-Go-Go Potassium Channels / genetics
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Immunohistochemistry
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Kaplan-Meier Estimate
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Lymph Nodes / chemistry
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Male
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Middle Aged
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Neoplasm Invasiveness
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Proportional Hazards Models
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RNA, Messenger / analysis
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Reverse Transcriptase Polymerase Chain Reaction
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Treatment Outcome
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Up-Regulation
Substances
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Biomarkers, Tumor
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Ether-A-Go-Go Potassium Channels
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KCNH1 protein, human
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RNA, Messenger