This study sought to evaluate the impact of an online self-learning module on nurse knowledge and use of the Lexi-Comp feature of the Pyxis MedStation Rx 2000 system, a point-of-care medication delivery system. Data were collected among nurse-users at a community-based healthcare organization (N = 41). Pre- and post-training surveys were used to evaluate training effects. After training, completion of the tutorial and knowledge and use of the Lexi-Comp feature increased by 23% and 56%, respectively. One month after training, a drop in medication errors on administration at the healthcare organization was observed. These findings suggest that use of evaluative and instructional tools would improve integration of technology and clinical practice and improve patient outcomes in medication error reduction.