Abstract
An efficient, one-pot synthetic protocol toward triazinane diones, a rather unexplored class of heterocyclic scaffolds combining phosphonates, nitriles, aldehydes, and isocyanates is described. The optimization of the reaction, synthesis of a small library of different triazinane diones, as well as alternative routes toward the triazinane dione scaffold are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Cyclization
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Isocyanates / chemistry
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Ketones / chemical synthesis*
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Ketones / chemistry
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Molecular Structure
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Nitriles / chemistry
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Organophosphonates / chemistry
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Small Molecule Libraries
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Stereoisomerism
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Triazines / chemical synthesis*
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Triazines / chemistry
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Urea / analogs & derivatives
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Urea / chemical synthesis*
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Urea / chemistry
Substances
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Aldehydes
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Isocyanates
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Ketones
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Nitriles
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Organophosphonates
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Small Molecule Libraries
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Triazines
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Urea