Abstract
We have shown that plasma apolipoprotein E is significantly decreased in treatment-free subjects with schizophrenia spectrum and bipolar disorder but increases after treatment in bipolar disorder. Levels of apolipoprotein D were not changed by treatment. Hence changed apolipoprotein E could be involved in abnormalities in lipid homeostasis in some subjects with psychiatric diseases.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Antipsychotic Agents / therapeutic use
-
Apolipoproteins E / blood*
-
Bipolar Disorder / blood*
-
Blotting, Western
-
Chlorpromazine / therapeutic use
-
Female
-
Humans
-
Lithium Carbonate / therapeutic use
-
Male
-
Psychotic Disorders / blood
-
Psychotic Disorders / drug therapy
-
Schizophrenia / blood*
-
Schizophrenia / drug therapy
-
Treatment Outcome
Substances
-
Antipsychotic Agents
-
Apolipoproteins E
-
Lithium Carbonate
-
Chlorpromazine