Coexistence of acetylcholine and calcitonin gene-related peptide in the vestibular efferent neurons in the rat

K Ohno; N Takeda; M Yamano; T Matsunaga; M Tohyama

doi:10.1016/0006-8993(91)91686-u

Coexistence of acetylcholine and calcitonin gene-related peptide in the vestibular efferent neurons in the rat

Brain Res. 1991 Dec 6;566(1-2):103-7. doi: 10.1016/0006-8993(91)91686-u.

Authors

K Ohno¹, N Takeda, M Yamano, T Matsunaga, M Tohyama

Affiliation

¹ Department of Otolaryngology, Osaka University Medical School, Japan.

PMID: 1814528
DOI: 10.1016/0006-8993(91)91686-u

Abstract

An immunocytochemical study combined with the retrograde tracer technique was performed in the rat to assess the vestibular efferent system. All 3 neuron groups which give rise to axons terminating on the vestibular end-organs were cholinergic, i.e., a group dorsolateral to the genu of the facial nerve (DL), a group dorsomedial to this genu (M), and scattered cells in the parvocellular reticular nucleus (PCRt). In addition, we further demonstrated that about 55% of the cholinergic cells in DL had calcitonin gene-related peptide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholine / analysis*
Animals
Axons / ultrastructure
Calcitonin Gene-Related Peptide / analysis*
Choline O-Acetyltransferase / analysis*
Efferent Pathways / cytology*
Efferent Pathways / enzymology
Immune Sera
Immunohistochemistry
Male
Neurons / cytology*
Neurons / enzymology
Rats
Rats, Inbred Strains
Vestibular Nuclei / cytology*
Vestibular Nuclei / enzymology

Substances

Immune Sera
Choline O-Acetyltransferase
Calcitonin Gene-Related Peptide
Acetylcholine