Behavioral changes induced by the thyrotropin-releasing hormone analogue, RGH 2202

Peptides. 1991 Nov-Dec;12(6):1309-13. doi: 10.1016/0196-9781(91)90212-8.

Abstract

The behavioral activity of the thyrotropin-releasing hormone (TRH) analogue, L-6-ketopiperidine-2- carbonyl-leucyl-L-prolinamide (RGH 2202), has been studied in the rat. The number of errors in a radial maze test was reduced after acute intraperitoneal (IP) injection of RGH 2202 at the dose of 5 or 10 mg/kg. Grooming activity was increased with a lower dose, 1 mg/kg. Hypoxia-induced amnesia, as assessed with active and passive avoidance behavior tests, was reversed in rats treated with 5 or 10 mg/kg of the drug. The loss of learning and memory capacity shown by aged rats in the same behavioral tests was also reduced after injection of RGH 2202. In a test for sexual activity of male rats, the higher dose of the drug induced a facilitation of mounting and ejaculations, while smaller doses were ineffective. The rotorod test revealed a decreased number of falls in animals treated with 5 or 10 mg/kg of RGH 2202. In all behavioral tests, the same doses of natural thyrotropin-releasing hormone (TRH) were less effective, indicating that this analogue may be qualified as a potentially active drug in human pathologies.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Behavior, Animal / drug effects*
  • Discrimination Learning / drug effects
  • Dose-Response Relationship, Drug
  • Grooming / drug effects
  • Male
  • Memory / drug effects
  • Rats
  • Rats, Inbred Strains
  • Sexual Behavior, Animal / drug effects
  • Spatial Behavior
  • Thyrotropin-Releasing Hormone / administration & dosage
  • Thyrotropin-Releasing Hormone / analogs & derivatives*
  • Thyrotropin-Releasing Hormone / pharmacology

Substances

  • Thyrotropin-Releasing Hormone
  • posatirelin