Is experimental endotoxaemia in humans suitable for simulating antibiotic pharmacokinetics in sepsis and septic shock? A pilot study using the model compound fosfomycin

Int J Antimicrob Agents. 2008 Mar;31(3):291-2. doi: 10.1016/j.ijantimicag.2007.10.018. Epub 2007 Dec 21.
No abstract available

Publication types

  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use*
  • Endotoxemia
  • Fosfomycin / pharmacokinetics*
  • Fosfomycin / therapeutic use*
  • Humans
  • Lipopolysaccharides / administration & dosage
  • Male
  • Pilot Projects
  • Sepsis / drug therapy*
  • Shock, Septic / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Lipopolysaccharides
  • Fosfomycin