Fine-mapping of a marbling trait to a 2.9-cM region on bovine chromosome 7 in Japanese Black cattle

Anim Genet. 2008 Feb;39(1):79-83. doi: 10.1111/j.1365-2052.2007.01676.x. Epub 2007 Dec 19.

Abstract

To locate quantitative trait loci (QTL) for intramuscular fat deposition (marbling) in a local population of Japanese Black cattle, we performed a genome scan using a paternal half-sib family of Bull A. A marbling QTL was mapped in the region flanked by DIK0079 (20.7 cM) and TGLA303 (39.3 cM) on bovine chromosome (BTA) 7, affecting 5.0% of the total family variance. Haplotype analysis of the QTL region revealed that the marbling-increasing Q allele was transmitted from the dam. On the other hand, Bull B, a maternal half-sib of Bull A, did not receive the Q allele from its dam, based on the following findings: (i) a marbling QTL on BTA7 was not detected in the Bull B paternal half-sib family; (ii) recombination between DIK0079 (20.7 cM) and RM006 (25.4 cM) in the QTL region was observed in the maternal chromosome of Bull B; and (iii) the Q-harbouring steers from Bull A exhibited significantly higher marbling than the steers from Bull B and the remaining steers from Bull A. To precisely compare the maternal chromosomes of both bulls, we constructed a bacterial artificial chromosome contig covering the region between DIK0079 and RM006 and developed DNA markers. The recombination occurred between DIK8042 and DIK8044, indicating that the marbling QTL was in a 2.9-cM region flanked by DIK0079 and DIK8044.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / anatomy & histology*
  • Alleles
  • Animals
  • Breeding
  • Cattle / anatomy & histology*
  • Cattle / classification
  • Cattle / genetics*
  • Chromosomes, Artificial, Bacterial / genetics
  • Female
  • Haplotypes
  • Japan
  • Male
  • Meat
  • Microsatellite Repeats
  • Muscle, Skeletal / anatomy & histology
  • Phenotype
  • Quantitative Trait Loci*
  • Species Specificity