Abstract
We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. Efficacy was -0.4% (95% CI: -19.4 to 15.6) for clinically-diagnosed OM, 5.1% (95% CI: -51.5 to 40.6) for severe OM, and 64% (95% CI: -34% to 90%) for vaccine serotype pneumococcal OM suggesting that this vaccine is efficacious for pneumococcal OM in this high risk population.
Publication types
-
Randomized Controlled Trial
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Heptavalent Pneumococcal Conjugate Vaccine
-
Humans
-
Indians, North American*
-
Infant
-
Meningococcal Vaccines / immunology*
-
Meningococcal Vaccines / therapeutic use
-
Otitis Media / immunology
-
Otitis Media / therapy*
-
Pneumococcal Infections / immunology*
-
Pneumococcal Infections / therapy*
-
Pneumococcal Vaccines / immunology*
-
Pneumococcal Vaccines / therapeutic use
-
United States
Substances
-
Heptavalent Pneumococcal Conjugate Vaccine
-
Meningococcal Vaccines
-
Pneumococcal Vaccines