Prediction model for lethal outcome after operation for thoracoabdominal aortic aneurysm (TAAA) has been constructed based on assessment of preoperative risk factors. The main risk factors of lethal outcome at TAAA repair are: Crawford's operation (OR 12.25), deep hypothermia and circulatory arrest (OR 10.86), renal failure (OR 6.8), coronary heart disease (OR 2.49), chronic non-specific lung diseases (OR 2.29), age >50 years (OR 2.18), TAAA of II type by Crawford (OR 2.12). The prognostic system permits to access individual risk with high accuracy including at the patients with combination of different risk factors.