Abstract
A synthesis of the C(1)-C(11) fragment of apoptolidin A has been accomplished by a convergent route involving the stereoselective glycosidation of 9 and the Suzuki cross-coupling reaction of bromodienoate 7 and the vinylborane generated via chemoselective hydroboration of diyne 6 with diisopinocampheylborane.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemical synthesis
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Alkynes / chemistry
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Carbon / chemistry*
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Molecular Structure
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Propanols / chemical synthesis
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Propanols / chemistry
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Thioglycosides / chemical synthesis
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Thioglycosides / chemistry
Substances
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Alkynes
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Macrolides
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Propanols
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Pyrones
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Thioglycosides
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apoptolidin A
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Carbon
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propargyl alcohol