Rho signaling inhibitor, Y-27632, inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model

Chin Med J (Engl). 2007 Dec 20;120(24):2304-7.

Authors

Feng Xue¹, Jian-jun Zhang, Feng Qiu, Ming Zhang, Xiao-song Chen, Qi-gen Li, Long-zhi Han, Zhi-feng Xi, Qiang Xia

Affiliation

¹ Organ Transplantation Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

PMID: 18167222

No abstract available

MeSH terms

Actins / chemistry
Amides / therapeutic use*
Animals
Apoptosis / drug effects
Cytoskeleton / drug effects
Enzyme Inhibitors / therapeutic use*
Female
Liver Neoplasms, Experimental / drug therapy*
Liver Neoplasms, Experimental / pathology
Mice
Neoplasm Invasiveness
Neoplasm Metastasis
Pyridines / therapeutic use*
ras Proteins / analysis
rho-Associated Kinases / analysis
rho-Associated Kinases / antagonists & inhibitors*
rhoA GTP-Binding Protein / analysis
rhoC GTP-Binding Protein

Substances

Actins
Amides
Enzyme Inhibitors
Pyridines
Y 27632
rho-Associated Kinases
Rhoc protein, mouse
ras Proteins
rhoA GTP-Binding Protein
rhoC GTP-Binding Protein