Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma

J Pediatr Hematol Oncol. 2008 Jan;30(1):63-5. doi: 10.1097/MPH.0b013e318159a510.

Abstract

Hepatic veno-occlusive disease (HVOD) is one of the major potential complications associated with high-dose chemotherapy with stem cell transplantation in children. However, esophageal varix rupture after HVOD has, to our knowledge, never been reported before. Here we report a case of a 4-year-old boy with stage 4 neuroblastoma with potentially fatal HVOD followed by esophageal varix rupture and massive intestinal bleeding after high-dose chemotherapy with autologous peripheral blood stem cell transplantation. We successfully treated him by endoscopic variceal ligation and administration of somatostatin analog.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Child, Preschool
  • Endoscopy, Digestive System
  • Esophageal and Gastric Varices / etiology*
  • Hematopoietic Stem Cell Transplantation*
  • Hemorrhage / etiology
  • Hemorrhage / pathology
  • Hemorrhage / therapy
  • Hepatic Veno-Occlusive Disease / etiology*
  • Hepatic Veno-Occlusive Disease / pathology
  • Hepatic Veno-Occlusive Disease / therapy
  • Hormones / administration & dosage
  • Hormones / adverse effects
  • Humans
  • Intestinal Diseases / etiology
  • Intestinal Diseases / pathology
  • Intestinal Diseases / therapy
  • Male
  • Neuroblastoma / complications*
  • Neuroblastoma / pathology
  • Neuroblastoma / therapy
  • Rupture, Spontaneous / etiology*
  • Rupture, Spontaneous / pathology
  • Rupture, Spontaneous / therapy
  • Somatostatin / administration & dosage
  • Somatostatin / analogs & derivatives
  • Transplantation, Autologous

Substances

  • Hormones
  • Somatostatin