Abstract
Pancreatic infiltration with leukemic cells is a rare manifestation of acute lymphoblastic leukemia. There are only a few reported cases. We report the clinical and radiologic findings of a 4-year-old boy with mature B-cell acute lymphoblastic leukemia and pancreatic involvement. A computed tomography scan of his abdomen demonstrated diffuse hypodense lesions in the pancreas. Plasma amylase and lipase levels at that time were high, but no signs of hypoglycemia or hyperglycemia were observed. After 2 cycles of chemotherapy, the lesions in his pancreas, liver, and kidney disappeared, and his pancreatitis resolved as well. At 11 months' follow-up, after completion of therapy, the patient continues to be in remission.
MeSH terms
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Acute Disease
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Amylases / blood
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Child, Preschool
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Diagnosis, Differential
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Humans
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Kidney Neoplasms / blood
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Kidney Neoplasms / diagnostic imaging
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Kidney Neoplasms / drug therapy
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Kidney Neoplasms / secondary
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Leukemia, B-Cell / blood
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Leukemia, B-Cell / diagnostic imaging*
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Leukemia, B-Cell / drug therapy*
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Lipase / blood
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Liver Neoplasms / blood
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / drug therapy
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Liver Neoplasms / secondary
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Male
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Pancreatic Neoplasms / blood
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Pancreatic Neoplasms / diagnostic imaging*
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Pancreatic Neoplasms / drug therapy*
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Pancreatic Neoplasms / secondary
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Pancreatitis / blood
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Pancreatitis / diagnostic imaging
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Pancreatitis / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnostic imaging*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Tomography, X-Ray Computed