The ratio of disappearance of bladder tumors after conventional irradiation (i.e. 45 Gy) is about 30-40%. At least this is the percentage resulting from the study of specimens obtained with total cystectomy, a procedure that remains the usual treatment of these infiltrating cancers. For 30 patients (29 T3 and 1 T2), we have implemented a radio-chemotherapeutic procedure associating 24-Gy radiation to a sensitizing chemotherapy from D1 to D3 and from D15 to D17. Complete response was obtained in 75% of all patients. In one half of the cases in which the response was total, we abstained from removing the bladder, and have noted no signs of recurrence so far.