Abstract
The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Behavior, Animal / drug effects
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Colistin / administration & dosage
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Colistin / adverse effects*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Humans
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Injections, Intravenous
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Kidney / drug effects*
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Kidney / pathology
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Kidney Diseases / chemically induced
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Mesylates / administration & dosage
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Mesylates / adverse effects*
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Motor Activity / drug effects
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Rats
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Rats, Sprague-Dawley
Substances
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Anti-Bacterial Agents
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Mesylates
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methanesulfonic acid
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Colistin