Carbon nanotubes as structural nanofibers for hyaluronic acid hydrogel scaffolds

Biomacromolecules. 2008 Feb;9(2):505-9. doi: 10.1021/bm7009976. Epub 2008 Jan 11.

Abstract

We have successfully dispersed functionalized single-walled carbon nanotubes (SWNTs) within hyaluronic acid-water solutions. Hybrid hyaluronic acid (HA) hydrogels with SWNTs were then formed by cross-linking with divinyl sulfone. We have found a considerable change in the morphology of the lyophilized hybrid hydrogels compared to HA hydrogels. The high water uptake capacity, an important property of HA hydrogels, remained almost unchanged after 2 wt % SWNT (vs HA) incorporation, despite a dramatic enhancement in the dynamic mechanical properties of the hybrid hydrogels compared to native ones. We have found a 300% enhancement in the storage modulus of hybrid hydrogel with only 2 wt % of SWNTs vs HA (0.06 wt % vs total weight including water content). This apparent contradiction can be explained by a networking effect between SWNTs, mediated by HA chains. As in biological tissue, HA plays a dual role of matrix and linker for the rigid reinforcing nanofibers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hyaluronic Acid / chemistry*
  • Hydrogels / chemistry*
  • Nanotubes, Carbon / chemistry*
  • Tissue Engineering / methods
  • Tissue Scaffolds / chemistry*

Substances

  • Hydrogels
  • Nanotubes, Carbon
  • Hyaluronic Acid