Synthesis of 3-substituted-3,4-dihydro-2H-1,3-benzothiazin- 2-ones via a highly regioselective palladium-catalyzed carbonylation of 2-substituted-2,3-dihydro-1,2-benzisothiazoles

Gwenaella Rescourio; Howard Alper

doi:10.1021/jo702146n

Synthesis of 3-substituted-3,4-dihydro-2H-1,3-benzothiazin- 2-ones via a highly regioselective palladium-catalyzed carbonylation of 2-substituted-2,3-dihydro-1,2-benzisothiazoles

J Org Chem. 2008 Feb 15;73(4):1612-5. doi: 10.1021/jo702146n. Epub 2008 Jan 11.

Authors

Gwenaella Rescourio¹, Howard Alper

Affiliation

¹ Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.

PMID: 18186646
DOI: 10.1021/jo702146n

Abstract

A novel synthesis of 3-substituted-3,4-dihydro-2H-1,3-benzothiazin-2-ones is described herein. The strategy relies on a highly regioselective palladium-catalyzed carbonylation of 2-substituted-2,3-dihydro-1,2-benzisothiazoles to give the corresponding 3,4-dihydro-2H-1,3-benzothiazin-2-one derivatives in good to excellent yields.