Synthesis of natural products from the Indian neem tree Azadirachta indica

Org Lett. 2008 Feb 21;10(4):569-72. doi: 10.1021/ol7027898. Epub 2008 Jan 15.

Abstract

The synthesis of five natural products (3, 6, 7, 10, and 14), isolated from the Indian neem tree Azadirachta indica, is reported from a common intermediate (2). The judicious choice of transacetalization conditions allows efficient access to both the azadirachtinin (9 and 10) and the azadirachtin (3, 6, 7, and 14) skeletons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azadirachta / chemistry*
  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • India
  • Limonins / chemical synthesis*
  • Limonins / chemistry
  • Molecular Structure

Substances

  • Biological Products
  • Limonins
  • azadirachtin