Abstract
Based on 139 cases collected in 36 months, the authors show that neonatal sepsis and meningitis with Gram negative bacilli represent 62.33% of confirmed neonatal sepsis (223 cases out of 6,784 neonatal hospitalisations). 53.96% of cases are manifest within the first 72 hours of life. 35.25% of these infants are preemies. The principal predisposing factors are: foul-smelling leukorrhea (45.23%), prolonged rupture of membranes (26.62%) and notion of resuscitation (36.69%). The most important clinical signs are: thermal dysregulation (47.48%), tonus disturbances (35.97%) and respiratory distress (25.90%). Sepsis make up 85.61% of cases; the principal germs isolated being: Acinetobacter (21.58%), Pseudomonas (15.83%), Escherichia coli (14.39%), Enterobacter (12.95%), Klebsiella (11.51%). Of the germs isolated, 27.78% were resistant to initial treatment with the association ampicillin gentamicin. Mortality rate was 46.76%.
MeSH terms
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Acinetobacter / drug effects
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Acinetobacter / isolation & purification
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Age Factors
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Anti-Bacterial Agents / pharmacology
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Bacteremia / diagnosis
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Bacteremia / epidemiology*
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Bacteremia / microbiology
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Cameroon / epidemiology
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Enterobacter / drug effects
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Enterobacter / isolation & purification
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Escherichia coli / drug effects
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Escherichia coli / isolation & purification
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Female
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / isolation & purification*
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Gram-Negative Bacterial Infections / diagnosis
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Gram-Negative Bacterial Infections / epidemiology*
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Infant, Newborn
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Klebsiella / drug effects
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Klebsiella / isolation & purification
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Male
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Meningitis, Bacterial / diagnosis
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Meningitis, Bacterial / epidemiology*
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Meningitis, Bacterial / microbiology
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Prognosis
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Proteus / drug effects
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Proteus / isolation & purification
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Pseudomonas / drug effects
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Pseudomonas / isolation & purification
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Sex Factors