Abstract
A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1.
MeSH terms
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Animals
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Apoptosis / physiology*
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / physiology*
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Genes, myc / physiology*
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Homeostasis
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Humans
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Inhibitor of Apoptosis Proteins / physiology*
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Repressor Proteins / physiology*
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Signal Transduction
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Inhibitor of Apoptosis Proteins
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MXD1 protein, human
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Repressor Proteins