Esmolol facilitated extubation in a patient with severe systolic dysfunction following myocardial infarction

Hellenic J Cardiol. 2007 Nov-Dec;48(6):380-4.

Abstract

We describe the case of a 59-year-old-man with acute myocardial infarction and severely impaired left ventricular systolic function who was intubated because of recurrent ventricular fibrillation in the setting of coronary angioplasty. Repeated ventilator weaning attempts and extubation initially failed, as severe tachycardia and hypertension occurred each time the patient began to awaken. Pre-treatment with esmolol infusion prevented the above haemodynamic changes, allowing successful extubation. Esmolol administration at ventilator weaning seems to be a safe and effective option, even in selected patients with impaired left ventricular contractility.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic beta-Antagonists / administration & dosage*
  • Coronary Angiography
  • Follow-Up Studies
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Myocardial Contraction / drug effects
  • Myocardial Contraction / physiology*
  • Myocardial Infarction / complications*
  • Myocardial Infarction / diagnostic imaging
  • Myocardial Infarction / physiopathology
  • Propanolamines / administration & dosage*
  • Severity of Illness Index
  • Systole
  • Ventilator Weaning / methods*
  • Ventricular Dysfunction, Left / drug therapy*
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Dysfunction, Left / physiopathology

Substances

  • Adrenergic beta-Antagonists
  • Propanolamines
  • esmolol