Course of preeclamptic glomerular injury after delivery

Am J Physiol Renal Physiol. 2008 Mar;294(3):F614-20. doi: 10.1152/ajprenal.00470.2007. Epub 2008 Jan 16.

Abstract

We evaluated the early postpartum recovery of glomerular function over 4 wk in 57 women with preeclampsia. We used physiological techniques to measure glomerular filtration rate (GFR), renal plasma flow, and oncotic pressure (pi(A)) and computed a value for the two-kidney ultrafiltration coefficient (K(f)). Compared with healthy, postpartum controls, GFR was depressed by 40% on postpartum day 1, but by only 19% and 8% in the second and fourth postpartum weeks, respectively. Hypofiltration was attributable solely to depression, at corresponding postpartum times, of K(f) by 55%, 30%, and 18%, respectively. Improvement in glomerular filtration capacity was accompanied by recovery of hypertension to near-normal levels and significant improvement in albuminuria. We conclude that the functional manifestations of the glomerular endothelial injury of preeclampsia largely resolve within the first postpartum month.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Female
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Kidney Glomerulus / physiopathology*
  • Models, Biological
  • Postpartum Period / physiology
  • Pre-Eclampsia / physiopathology*
  • Pregnancy