Abstract
We describe the development of nonsusceptibility to daptomycin and vancomycin during treatment for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia associated with infective endocarditis and probable septic thrombophlebitis in a uremic patient. MRSA bacteremia persisted during glycopeptide and subsequent daptomycin treatment but cleared after 5 days' treatment with linezolid and fusidic acid.
MeSH terms
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Aged
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Anti-Bacterial Agents / pharmacology*
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Bacteremia / drug therapy
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Bacteremia / microbiology*
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Daptomycin / pharmacology*
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Daptomycin / therapeutic use
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Drug Resistance, Bacterial*
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Endocarditis / drug therapy
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Endocarditis / microbiology*
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Humans
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Male
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Methicillin Resistance*
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Microbial Sensitivity Tests
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Taiwan
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Vancomycin / pharmacology*
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin
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Daptomycin