Genetic aspects in attention-deficit/hyperactivity disorder

J Neural Transm (Vienna). 2008;115(2):305-15. doi: 10.1007/s00702-007-0839-9. Epub 2008 Jan 16.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder among children and adolescents with high heritability. Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large-scale genome wide association studies, gene-environement interaction studies, and pharmacogenetics. This article comprehensively reviews the latest findings on the genetics of ADHD.

Publication types

  • Review

MeSH terms

  • Animals
  • Attention Deficit Disorder with Hyperactivity / genetics*
  • GPI-Linked Proteins
  • Genetics*
  • Humans
  • Neural Cell Adhesion Molecules / genetics
  • Risk Factors

Substances

  • GPI-Linked Proteins
  • Neural Cell Adhesion Molecules
  • neurotrimin