HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives

Chirality. 2008 Jun;20(6):775-80. doi: 10.1002/chir.20518.

Abstract

The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak IA stationary phase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Chromatography, High Pressure Liquid / methods*
  • Circular Dichroism
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Pyrroles / chemistry*
  • Pyrroles / isolation & purification*
  • Spectrophotometry, Ultraviolet
  • Stereoisomerism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Pyrroles