Abstract
The pattern of brain asymmetries was visualized on computed tomography (CT) scan in patients with a single acute cerebrovascular lesion. Patients were divided into those with typical or reversed frontal and/or occipital asymmetries. Among patients with a typical occipital asymmetry, those with left frontal or left basal ganglia lesions showed a significantly higher frequency of major depression and significantly higher depression scores than patients with similar lesion location but with reversed occipital asymmetry or those with a typical asymmetry and lesions in other (left or right) brain areas. Among patients with a reversed occipital asymmetry, there was no significant association between left frontal or left basal ganglia lesions and depression. This study demonstrates that the previously reported significant association between post-stroke major depression and lesion location is restricted to patients with a typical occipital asymmetry and is not present in patients with a reversed occipital asymmetry.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aphasia, Broca / diagnosis
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Aphasia, Broca / physiopathology
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Aphasia, Broca / psychology
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Basal Ganglia / physiopathology
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Cerebral Hemorrhage / diagnosis
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Cerebral Hemorrhage / physiopathology
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Cerebral Hemorrhage / psychology
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Cerebral Infarction / diagnosis
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Cerebral Infarction / physiopathology
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Cerebral Infarction / psychology
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Cerebrovascular Disorders / diagnosis
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Cerebrovascular Disorders / physiopathology*
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Cerebrovascular Disorders / psychology
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Depressive Disorder / diagnosis
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Depressive Disorder / physiopathology*
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Depressive Disorder / psychology
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Dominance, Cerebral / physiology*
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Frontal Lobe / physiopathology
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Humans
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Intracranial Embolism and Thrombosis / diagnosis
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Intracranial Embolism and Thrombosis / physiopathology
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Intracranial Embolism and Thrombosis / psychology
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Neurocognitive Disorders / diagnosis
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Neurocognitive Disorders / physiopathology*
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Neurocognitive Disorders / psychology
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Neuropsychological Tests
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Occipital Lobe / physiopathology
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Tomography, X-Ray Computed