Abstract
To determine risk for drug-resistant malaria parasites entering Madagascar from Comoros Islands, we screened travelers. For the 141 Plasmodium falciparum isolates detected by real-time PCR, frequency of mutant alleles of genes associated with resistance to chloroquine and pyrimethamine was high. International-level antimalarial policy and a regional antimalarial forum are needed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Antimalarials / therapeutic use
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Child, Preschool
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Chloroquine / therapeutic use
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Comoros / epidemiology
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Drug Resistance, Multiple / genetics*
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Female
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Humans
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Madagascar / epidemiology
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / epidemiology*
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Malaria, Falciparum / parasitology
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Male
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Plasmodium falciparum / isolation & purification*
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Polymerase Chain Reaction / methods
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Pyrimethamine / therapeutic use
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Travel*
Substances
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Antimalarials
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Chloroquine
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Pyrimethamine