Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism

O V Artem'eva; A V Koryaikina; A V Zor'kina

doi:10.1007/s10517-007-0103-1

Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism

Bull Exp Biol Med. 2007 Mar;143(3):331-3. doi: 10.1007/s10517-007-0103-1.

Authors

O V Artem'eva¹, A V Koryaikina, A V Zor'kina

Affiliation

¹ Department of Ambulatory Therapy and Functional Diagnostics, N. P. Ogarev Mordovian State University, Saransk.

PMID: 18225755
DOI: 10.1007/s10517-007-0103-1

Abstract

Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.

MeSH terms

Animals
Anti-Arrhythmia Agents / administration & dosage*
Antioxidants / administration & dosage*
Arrhythmias, Cardiac / drug therapy*
Arrhythmias, Cardiac / metabolism
Carbohydrate Metabolism / drug effects
Drug Synergism
Female
Lidocaine / administration & dosage*
Lipid Metabolism / drug effects
Lipid Peroxidation / drug effects
Male
Rats

Substances

Anti-Arrhythmia Agents
Antioxidants
Lidocaine