Nonparametric identification of population models: an MCMC approach

IEEE Trans Biomed Eng. 2008 Jan;55(1):41-50. doi: 10.1109/TBME.2007.902240.

Abstract

The paper deals with the nonparametric identification of population models, that is models that explain jointly the behavior of different subjects drawn from a population, e.g., responses of different patients to a drug. The average response of the population and the individual responses are modeled as continuous-time Gaussian processes with unknown hyperparameters. Within a Bayesian paradigm, the posterior expectation and variance of both the average and individual curves are computed by means of a Markov Chain Monte Carlo scheme. The model and the estimation procedure are tested on both simulated and experimental pharmacokinetic data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Animals
  • Computer Simulation
  • Data Interpretation, Statistical
  • Humans
  • Markov Chains*
  • Models, Biological*
  • Models, Statistical*
  • Monte Carlo Method*
  • Population Dynamics*