A synthesis of RGD model cyclic peptide by palladium-catalyzed carbonylative macrolactamization

Takayuki Doi; Seiji Kamioka; Sayaka Shimazu; Takashi Takahashi

doi:10.1021/ol702965r

A synthesis of RGD model cyclic peptide by palladium-catalyzed carbonylative macrolactamization

Org Lett. 2008 Mar 6;10(5):817-9. doi: 10.1021/ol702965r. Epub 2008 Jan 31.

Authors

Takayuki Doi¹, Seiji Kamioka, Sayaka Shimazu, Takashi Takahashi

Affiliation

¹ Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.

PMID: 18232700
DOI: 10.1021/ol702965r

Abstract

Cyclic peptidic RGD models were efficiently synthesized by Pd(P(t-Bu)3)2-catalyzed carbonylative macrolactamization in the presence of 4 A molecular sieves under 10 atm of carbon monoxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon Monoxide
Catalysis
Models, Molecular*
Molecular Structure
Palladium / chemistry*
Peptides, Cyclic / chemical synthesis*
Peptides, Cyclic / chemistry

Substances

Peptides, Cyclic
cyclic arginine-glycine-aspartic acid peptide
Palladium
Carbon Monoxide