Direct carbocyclization of aldehydes with alkynes: combining gold catalysis with aminocatalysis

Org Lett. 2008 Mar 6;10(5):1025-8. doi: 10.1021/ol800092p. Epub 2008 Jan 31.

Abstract

A combination of gold(I) complexes and amine bases catalyzes the 5-exo-dig cyclization of formyl alkynes. This direct alpha-functionalization of aldehydes with unactivated alkynes does not involve the use of preformed enol equivalents.